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Association between pulmonary tuberculosis and acid suppressive agents
  1. Shih-Wei Lai1,2,
  2. Cheng-Li Lin1,3,
  3. Kuan-Fu Liao4,5
  1. 1College of Medicine, China Medical University, Taichung, Taiwan
  2. 2Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
  3. 3Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
  4. 4College of Medicine, Tzu Chi University, Hualien, Taiwan
  5. 5Division of Hepatogastroenterology, Department of Internal Medicine, Taichung Tzu Chi Hospital, Taichung, Taiwan
  1. Correspondence to Dr Kuan-Fu Liao; kuanfuliaog{at}gmail.com

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Proton pump inhibitors therapy has been found to be associated with some comorbidities.1 Recently, one case-control study disclosed a positive association between tuberculosis and proton pump inhibitors therapy (OR=1.13; 95% CI 1.10 to 1.28),2 which was compatible with another case-control study in Taiwan (OR=1.31; 95% CI 1.22 to 1.41).3 Some points need to be discussed. Proton pump inhibitors and histamine-2 receptor antagonists have similar indications for acid-related gastrointestinal diseases, but little research explores the association between the risk of tuberculosis and histamine-2 receptor antagonists therapy. In order to explore this issue, a preliminary case-control study was conducted …

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