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Decreased expression of long non-coding LOC285194 predicts tumour progression and poor prognosis of hepatocellular carcinoma after curative hepatectomy
  1. Jianguo Qiu1,
  2. Gang Pan2,
  3. Ming Li3
  1. 1Department of Hepatobiliary surgery, The First Affiliated Hospital of Chonqing Medical University, Chongqing, China
  2. 2Department of General surgery, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China
  3. 3Hepatobiliary surgery, Chongqing Medical University, Chongqing, China
  1. Correspondence to Professor Ming Li, Chongqing, China; limingcyfyy945{at}163.com

Abstract

Background Long non-coding RNAs (LncRNAs) have been recently implicated as having oncogenic and tumour suppressor roles. LncRNA LOC285194 (LOC285194) expression was significantly reduced in a variety of tumour tissues and cell lines, which promotes cell proliferation and migration. The aim of the present study is to examine the expression pattern of LOC285194 and its clinical significance in hepatocellular carcinoma (HCC) patients after curative liver resection.

Materials and methods We examined the expression of LOC285194 in 120 HCC samples and controls from adjacent non-tumour tissues using real-time quantitative reverse transcription-PCR and analysed its correlation with clinical parameters and prognosis in these patients who have undergone curative hepatic resection with a median follow-up of 3.5 years.

Results The expression level of LOC285194 was significantly lower in tumour tissues and four liver cancer cell lines compared with adjacent normal tissues and normal liver cell line. Furthermore, a low expression of LOC285194 was significantly correlated with advanced tumour stage, microvascular invasion, tumour number and differentiation. Additionally, survival analysis showed that patients with low LOC285194 expression had a significantly worse overall and disease-free survival. Moreover, univariate and multivariate analyses showed that decreased expression of LOC285194 was an independent predictor of long-term survival.

Conclusions The low expression level of LOC285194 might be a novel candidate biomarker for predicting tumour progression and poor prognosis in HCC patients who have undergone hepatectomy and might be a potential target for gene therapy.

  • hepatocellular carcinoma
  • long non-coding RNAs
  • LOC285194
  • progression
  • survival
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Footnotes

  • Contributors ML designed the study; JQ and GP wrote the manuscript; GP and ML analysed the data and interpreted the results. JQ and GP equally contributed to the work. All the authors approved the final version to be published.

  • Funding This research was supported by Basic and Advanced Research Project of Science and Technology Commission of Chongqing Municipality (No. cstc2018jcyjAX0825).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The Research Ethics Board was also approved by the Research Ethics Board at the First Affiliated Hospital of Chongqing Medical University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request.

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