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Lipoprotein(a) and coronary artery disease in Chinese postmenopausal female patients: a large cross-sectional cohort study
  1. Shuo-Lin Liu,
  2. Na-Qiong Wu,
  3. Yuan-Lin Guo,
  4. Cheng-Gang Zhu,
  5. Ying Gao,
  6. Jing Sun,
  7. Rui-Xia Xu,
  8. Geng Liu,
  9. Qian Dong,
  10. Jian-Jun Li
  1. Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease,Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy ofMedical Sciences and Peking Union Medical College, Xicheng District, China
  1. Correspondence to Dr Jian-Jun Li, Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Xicheng District 100037, China; 13901010368{at}163.com; Dr Na-Qiong Wu, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; fuwainaqiongwu{at}163.com

Abstract

Background It has been reported that lipoprotein(a) (Lp(a)) is associated with the risk of cardiovascular disease. The present study aimed to examine the association of Lp(a) levels with the presence and severity of coronary artery disease (CAD) in female patients.

Methods A total of 3712 female patients who received coronary angiography were consecutively enrolled. The levels of Lp(a) were measured and compared among patients with or without CAD, myocardial infarction and menopause. Spearman correlation analysis and logistic regression analysis were used to examine the association of Lp(a) with the presence of CAD and the severity of coronary atherosclerosis assessed by Gensini score (GS).

Results The average of Lp(a) levels was elevated as age increased in female subjects. Notably, women after menopause had higher Lp(a) levels compared with that before menopause (16.8 mg/dL (IQR 7.54–41.12 mg/dL) vs 14.7 mg/dL (IQR 6.72–30.82 mg/dL), p=0.002). Furthermore, multiple logistic regression analysis identified that Lp(a)>30 mg/dL was an independent risk factor of CAD in the postmenopausal females (OR: 1.33, 95% CI: 1.08 to 1.63, p=0.007). Finally, Lp(a) had a positive correlation with GS (r=0.11, p<0.001), and Lp(a)>30 mg/dL was an independent risk factor for high GS (OR: 1.43, 95% CI: 1.14 to 1.79, p=0.02) in the postmenopausal females.

Conclusion Circulating Lp(a) levels were independently associated with the presence and severity of CAD in the postmenopausal females, suggesting that Lp(a) may be useful for prevention and risk-stratification of CAD in female individuals.

  • lipoprotein(a)
  • coronary artery disease
  • Gensinin score
  • females
  • menopause
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Footnotes

  • Correction notice This article has been corrected since it was published Online First. Dr Na-Qiong Wu has been added as a corresponding author.

  • Contributors JJL and NQW planned the study, SL-L, Y-LG, C-GZ, YG, JS, R-XX, GL, QD conducted a survey, SLL and N-QW wrote the article, SLL submitted the study.

  • Funding This work was partially supported by the Capital Health Development Fund (201614035), and CAMS Major Collaborative Innovation Project (2016-I2M-1-011) awarded to J-JL.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.

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