Article Text

other Versions

Reversible heart failure: the role of inflammatory activation
  1. Tim Robinson,
  2. Alyson Smith,
  3. Kevin S Channer
  1. Cardiology Department, Royal Hallamshire Hospital, Sheffield, UK
  1. Correspondence to Professor Kevin S Channer, Cardiology Department, Royal Hallamshire Hospital, Sheffield S10 2JF, UK; kevin.channer{at}


Heart failure is increasingly common in western populations and is an inevitable consequence of the improved survival after myocardial infarction, and of an ageing population. Heart failure is usually relentlessly progressive as the maladaptive processes triggered by the physiological changes of the condition lead to further deterioration. However, in certain circumstances, heart failure is transient or potentially reversible when it occurs as part of intense systemic inflammatory activation. This review considers the role of inflammation in the aetiology of heart failure, and illustrates the strategies which have been used to modify the inflammatory response with anonymised clinical case reports.

  • Cardiology
  • heart failure

Statistics from


  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.