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Purpura fulminans
  1. Syed Noaman Ali1,
  2. Amanda Kauffman2,
  3. Misbahuddin Syed2
  1. 1 University of South Florida College of Medicine, Tampa, Florida, USA
  2. 2 Internal and Hospital Medicine, Moffitt Cancer Center, Tampa, Florida, USA
  1. Correspondence to Dr Misbahuddin Syed, Internal and Hospital Medicine, Moffitt Cancer Center, Tampa, FL 33612-9416, USA; Misbahuddin.Syed{at}

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Retiform purpura is a skin condition caused by compromised vasculature, leading to progressive purpuric skin changes, ischaemia and necrosis. There are infectious and non-infectious aetiologies. Infectious pathophysiologic mechanisms may be from direct vascular injury, vascular occlusion from septic emboli and disseminated intravascular coagulation (DIC). This can develop into purpura fulminans, a rapidly progressive intravascular thrombotic disorder characterised by worsening haemorrhagic infarction of the skin, DIC, multiorgan dysfunction and death. …

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  • Contributors SNA, AK and MS prepared the manuscript. MS formatted the submitted images and performed the submission process to the journal.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.