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Claustrum hyperintensity as a marker of anti-NMDAR encephalitis
  1. Amlan Kusum Datta1,
  2. Uddalak Chakraborty1,
  3. Arpan Dutta1,
  4. Sudeshna Malakar2,
  5. Alak Pandit1
  1. 1 Neurology, Institute of Postgraduate Medical Education and Research Bangur Institute of Neurology, kolkata, West Bengal, India
  2. 2 Radiodiagnosis, Apollo Gleneagles Hospital, Kolkata, West Bengal, India
  1. Correspondence to Uddalak Chakraborty, Neurology, Institute of Postgraduate Medical Education and Research Bangur Institute of Neurology, kolkata 700020, West Bengal, India; uddaalakchakraborty{at}

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A young adult male patient presented with subacute onset, rapidly progressive cognitive impairment and refractory seizures and was diagnosed as definite anti N-methyl D-aspartate receptor (anti-NMDAR) antibody encephalitis as per criteria by Graus et al. (2016), following detection of culprit autoantibodies in serum.1 MRI of brain revealed bilateral T2-weighted image (T2WI)/fluid-attenuated inversion recovery (FLAIR) claustrum hyperintensities (figure 1). Previously, in a cohort of 34 patients,2 presenting with new-onset refractory epilepsy, 4 out of 34 patients showed bilateral claustrum FLAIR hyperintensities on MRI imaging, none …

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  • Contributors AKD and UC drafted the initial manuscript and collaborated in diagnosis and management of the patient; AD and SM collected the images, worked for critical content and revision of manuscript with review of literature; AP supervised the entire procedure and treatment of the patient.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.