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Solifenacin-induced acute urticaria and angioedema: a rare adverse effect
  1. Umer Younas,
  2. Omar Shafiq,
  3. Sahibzada Nasir Mansoor,
  4. Muhammad Tawab Khalil
  1. Physical Medicine & Rehabilitation, Armed Forces Institute of Rehabilitation Medicine, Rawalpindi, Pakistan
  1. Correspondence to Dr Umer Younas, Physical Medicine & Rehabilitation, Armed Forces Institute of Rehabilitation Medicine, Rawalpindi, Punjab, Pakistan; umeryounassp{at}


Antimuscarinics are first-line medication for management of overactive bladder with solifenacin being commonly prescribed. Angioedema is the swelling of mucosa and submucosal tissue. There are no published case reports of drug-induced angioedema involving solifenacin. We report a case of a 41-year-old man with spinal cord injury who presented with oedema of face, lips, tongue and associated pruritic urticaria after taking 5 mg of solifenacin. All other possible causes including food allergy, insect bite, hereditary angioedema, use of NSAIDs, ACE inhibitors and antibiotics were ruled out. The temporal association between solifenacin and angioedema and complete resolution of symptoms after discontinuing the drug suggest that solifenacin was the most probable cause of angioedema in our patient.

  • adverse events
  • rehabilitation medicine

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  • Contributors UY initially identified, managed and monitored the case. He conceptualised and designed the case report. He is the guarantor of case report. OS drafted the case report in addition to extensive literature research before submission for final approval. SNM revised it critically for important intellectual content and gave final approval of version to be submitted. MTK performed detailed analysis and independent literature research to improve the manuscript in line with the kind recommendations made by the reviewers and critically revised the manuscript before resubmission for approval.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.