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Neuromyelitis optica as a cause of serious ventilatory compromise
  1. Domingos Sousa1,2,
  2. Ana Isabel Rodrigues1,
  3. Mourão Carvalho1,
  4. Rui Ferreira de Almeida3,
  5. Silvia Castro3,
  6. Daniel Nuñez3
  1. 1 Internal Medicine, Centro Hospitalar Do Algarve EPE, Faro, Portugal
  2. 2 Universidade Da Beira Interior Faculdade De Ciências Da Saúde, Covilha, Portugal
  3. 3 Intensive Care Unit, Centro Hospitalar Do Algarve EPE, Faro, Portugal
  1. Correspondence to Domingos Sousa, Internal Medicine Department, Centro Hospitalar E Universitário Do Algarve, Unidade De Faro, Portugal; domingos.sousaa{at}

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The spectrum of diseases of optic neuromyelitis corresponds to a set of rare inflammatory and autoimmune diseases of the central nervous system (CNS), with consequent demyelination of CNS neurons that predominantly affects the spinal cord, optic nerve and brainstem causing respiratory insufficiency in 6.3% of cases. Neuromyelitis optica (NMO) was until recently considered a variant of multiple sclerosis (MS). Its aetiopathogenesis remains unknown, but recent advances describe an association with an autoimmunity production of IgG against the aquoporin-4 …

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  • Contributors Acquisition of data, clinical and imaging data review, literature review and final manuscript writing. AIR, MC RFdA, SC and DN: imaging data review, important intellectual contribution and final manuscript writing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests On behalf of all authors, the corresponding author states that there is no conflict of interest.

  • Patient consent for publication Consent obtained directly from patient(s).

  • Provenance and peer review Not commissioned; internally peer reviewed.