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Necrolytic migratory erythema: an important sign of glucagonoma
  1. Ming Cui1,
  2. Ruojun Wang2,
  3. Quan Liao1
  1. 1 Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  2. 2 Department of Dermatology, Peking University First Hospital, Beijing, China
  1. Correspondence to Professor Quan Liao, Department of General Surgery, Peking Union Medical College Hospital, Beijing 100730, China; lqpumc{at}

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A 44-year-old male patient presented with a 1-month history of progressive pruritic skin rash on the face, scrotal region and lower extremities. His medical history included multiple parathyroid adenomas and pituitary microadenoma. The family history was significant for his father having multiple endocrine neoplasia type 1 with hyperparathyroidism, pituitary adenoma and gastrinoma. Physical examination showed well-demarcated, erosive, erythematous patches and plaques on his face, lower legs and scrotal region (figure 1A). Laboratory investigations revealed a glucagon level of 679 pg/mL (normal range 0–200 pg/mL), …

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  • Contributors MC and RW drafted the manuscript. MC and QL were in charge of the patient and collected the data. MC did the follow-up of the patient. QL critically revised the manuscript. All authors approved the final version.

  • Funding This study was funded by the Chinese Academy of Medical Sciences Initiative for Innovative Medicine (2017-I2M-1-001) and the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences (2018PT32014).

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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