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Vitamin B12 deficiency presenting as acute febrile encephalopathy and retinopathy
  1. Nikhil Dongre1,
  2. Varun Kumar Singh2,
  3. Jayantee Kalita1,
  4. Usha Kant Misra1
  1. 1 Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
  2. 2 Neurology, Institute of Medical Sciences,Banaras Hindu University, Varanasi, Uttar Pradesh, India
  1. Correspondence to Professor Usha Kant Misra, Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India; drukmisra{at}

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Vitamin B12 deficiency causes macrocytic anaemia, peripheral neuropathy, myelin loss in posterior and lateral columns of spinal cord (subacute combined degeneration of cord) and a wide variety of neuropsychiatric symptoms in adults.1 In neonates and children, vitamin B12 deficiency manifests with developmental delay, regression of milestones, seizures, encephalopathy and involuntary movements.2 We report a patient with vitamin B12 deficiency who presented with acute febrile illness. Through this communication we highlight the acute presentation of vitamin B12 deficiency for which the patient consented.

Case report

A 23-year-old female, was admitted with complaints of mild fever, five to six loose motions and vomiting 2 weeks back. Three days later she had recurrence of diarrhoea which was followed by weakness of both lower and upper limbs at night. Patient had loose stools before presenting to our hospital. As she had no blood or mucus associated with diarrhoea it was presumed …

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  • Contributors ND: Patients care and data collection. VKS: Supervision of data. JK: Supervision of patient care and editing. UKM: Conceptualising and writing the draft.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Parental/guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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