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Hypothermia induced by quetiapine
  1. Ami Schattner1,2,
  2. Ina Dubin2
  1. 1 Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem, Israel
  2. 2 Department of Medicine, Laniado Hospital, Sanz Medical Centre, Netanya, Israel
  1. Correspondence to Professor Ami Schattner, Hebrew University Hadassah Medical School, Yerushalayim 91120, Israel; amischatt{at}

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An 89-year-old woman was brought to the emergency department, responding only to pain (GCS 6), with a rectal temperature of 28.5°C, hypotension (68/40), bradycardia (35/min) and bradypnoea. The remainder of the examination was unremarkable.

She was living at home with her son and a caretaker, confined to bed/wheelchair with a history of Alzheimer’s dementia, falls, hypothyroidism (on replacement), hypertension and chronic atrial fibrillation (AF) (on amlodipine 5 mg four times a day, propranolol 10 mg three times a day). Other regular medications included quetiapine (Seroquel) 125 mg four times a day and brotizolam 0.25 mg.

Laboratory tests showed no evidence of infection or metabolic disorder except acidosis (pH 7.27). Thyoid stimulating hormone (TSH) and cortisol levels were normal. Chest X-ray, head CT and urinalysis were unremarkable; ECG showed slow AF. …

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  • Contributors AS wrote the manuscript with the participation of ID. ID and AS planned the study. AS conducted a survey of the literature and composed the manuscript, aided by ID.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Next of kin consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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