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Analysis of situation of acute coronary syndrome based on the date of the Improving Care for Cardiovascular Disease in China–Acute Coronary Syndrome (CCC-ACS) project: single-centre observational study
  1. Jiaying Li,
  2. Hui Peng,
  3. Xiexiong Zhao,
  4. Nana You,
  5. Yuyan Wu,
  6. Junwen Wang,
  7. Huiling Chen,
  8. Huiting Tang,
  9. Xiaoyu Zhou,
  10. Xiaogang Li,
  11. Weihong Jiang
  1. Cardiology, Central South University, Third Xiangya Hospital, Changsha, Hunan, China
  1. Correspondence to Professor Weihong Jiang, Cardiology, Central South University Third Xiangya Hospital, Changsha, Hunan, China; 2806572418{at}


Background We are currently faced with an increasing burden of cardiovascular disease in China and the inadequacy of the application of guidelines in clinical practice. In the past decade, China has been strengthening the healthcare system, but it still lacked a national performance measurement system and an appropriate quality improvement strategy. Therefore, in order to improve the implementation of guideline recommendations in clinical practice, China has learnt from the successful experience of Get With The Guidelines project in 2014. Under the guidance of the Medical and Health Hospital of the National Health and Family Planning Commission, the Chinese Society of Cardiology and the American Heart Association jointly launched the Improving Care for Cardiovascular Disease in China (CCC) project. The project team provided an analysis report on the completion of key medical quality evaluation indicators of each hospital every month, supplied guidance through education, training, experience exchange and on-site investigation for problems, and certified hospitals with outstanding performance and obvious progress. The circle pattern, including evaluation, training, improvement and re-evaluation, will boost the guidelines compliance on clinical practice in China and improve the quality of medical services.

Methods This study was conducted in a centre of the Third Xiangya Hospital of Central South University. It included patients with ACS from December 2009 to December 2011 (n=225), patients with ACS in the Improving Care for Cardiovascular Disease in China–Acute Coronary Syndrome project coming from the Third Xiangya Hospital of Central South University (n=665), 12 hospitals in Hunan Province (n=4333) and 150 hospitals in China (n=63 641) from November 2014 to April 2017. It assessed the situation of drug therapy, hospitalisation day, mortality during hospitalisation, median of door-to-needle (D-to-N) time and median of door-to-balloon (D-to-B) time of patients with ST-segment elevation myocardial infarction (STEMI), the proportion of D-to-N within 30 min and D-to-B within 90 min, and the proportion of reperfusion therapy. Patients with ACS from the centre from November 2014 to April 2017 were divided into five groups (every 6 months as a group according to time). The study observed change trends in all the above-mentioned indexes.

Results Compared with before participating in the CCC project, there were increases after participating in the CCC project in the drug usage rates of aspirin, P2Y12 inhibitor (clopidogrel or ticagrelor), β-blocker, statin and angiotensin converting enzyme inhibitor (ACEI)/angiotensin-receptor blocker (ARB). Hospitalisation day and mortality during hospitalisation were shortened. D-to-N and D-to-B times of patients with STEMI were shorter. Compared with Hunan Province and China, the drug usage rates were higher; hospitalisation day and D-to-N time were shorter; D-to-B time was longer; and the proportion of reperfusion therapy was higher. The trend of drug usage rates was on the rise. There was no significant change in the hospitalisation day and D-to-N and D-to-B times. The mortality during hospitalisation showed a downward trend. The proportion of D-to-N within 90 min and reperfusion therapy showed upward trends.

Conclusion Quality of care for patients with ACS improved over time in the CCC project, including taking medicine following the guidelines, increased use of reperfusion therapy and faster time to treatment. Although overall mortality has improved, we also should attach importance to high-risk patients. The influence of the CCC project, which is based on guidelines on prognosis of ACS in the centre, presents an important clinical implication that it is necessary to enhance adherence to the guidelines in the treatment of ACS.

  • Improving Care for Cardiovascular Disease in China (CCC)
  • acute coronary syndrome (ACS)
  • analyse the situation
  • drug therapy
  • reperfusion therapy

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  • Contributors JL and HP planned the study. XZ, JW, HC and HT conducted the survey and collection. XL, YW and NY did the statistics. XZ submitted the study. JL finished writing the essay. WJ guaranteed the research progress and improved the manuscript.

  • Funding The study was supported by the National Natural Science Foundation of China Projects (numbers 81670335 and 81800271), the New XiangYa Talent Projects of the Third Xiangya Hospital of Central South University (number 20170304), the Natural Science Foundation of Hunan Province (number 2019JJ50920) and the Fundamental Research Funds for the Central Universities of Central South University (number 2019zzts1053).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval All selected individuals had signed an informed consent and had been approved by the ethics committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.