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Ibuprofen is a commonly prescribed non-steroidal anti-inflammatory drug, mainly used in the treatment of pain from various conditions such as headache, toothache, menstrual cramps, muscle aches or arthritis. Gastrointestinal side effects, nephrotoxicity and different cutaneous adverse effects (photosensitivity, angio-oedema and urticarial rashes) following ingestion of ibuprofen have been reported.1 Here, we describe a rare cutaneous adverse drug reaction, generalised bullous fixed drug eruption (GBFDE), where ibuprofen was the culprit drug.
A 20-year-old man presented with multiple painful bullous eruptions all over his body for the past 5 days. A day prior to the appearance of skin lesions, he had taken tablet ibuprofen for severe toothache. He had developed a few similar bullous lesions over his trunk a year ago following ibuprofen intake, which resolved spontaneously with hyperpigmentation. Examination …
Contributors DBB and AS contributed to initial patient assessment and follow-up, conception, drafting of the manuscript and final approval of the manuscript. AP and SC contributed to conception, critical revision of content and final approval of the manuscript. All authors are in agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Obtained.
Provenance and peer review Not commissioned; internally peer reviewed.
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