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Hydroxychloroquine and COVID-19
  1. Neeraj Sinha1,
  2. Galit Balayla2
  1. 1Pulmonary Transplant, University of Miami Miller School of Medicine, Miami, Florida, USA
  2. 2General Medicine, Central University of Venezuela, Caracas, Venezuela
  1. Correspondence to Dr Neeraj Sinha, Pulmonary Transplant, University of Miami Miller School of Medicine, Miami, FL 33136-1015, USA; nsinhamd{at}


Hydroxychloroquine and chloroquine are medications that have been used for a long time. Their most common use is for the treatment and prophylaxis of malaria. However, these antimalarial drugs are known to also have anti-inflammatory and antiviral effects and are used for several chronic diseases such as systemic lupus erythematosus with low adverse effects. The antiviral action of hydroxychloroquine and chloroquine has been a point of interest to different researchers due to its mechanism of action. Several in vitro studies have proven their effectiveness on severe acute respiratory syndrome virus and currently both in vitro and in vivo studies have been conducted on 2019 novel coronavirus (covid-19). The purpose of this article is to review the history and mechanism of actions of these drugs and the potential use they can have on the current covid-19 pandemic.

  • thoracic medicine
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  • Twitter Neeraj Sinha @md_neeraj

  • Contributors Both authors contributed equally to the preparation of manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • This article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.

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