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Association of mean arterial pressure with all-cause and cardiovascular mortality in young adults
  1. Shuo Sun1,
  2. Kenneth Lo2,
  3. Lin Liu1,
  4. Jiayi Huang1,
  5. Ying Qing Feng1,
  6. Ying-ling Zhou1,
  7. Yu-Qing Huang1
  1. 1 Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Academy of Medical Sciences, Guangzhou, China
  2. 2 Centre for Global Cardiometabolic Health, Department of Epidemiology, Brown University, Providence, Rhode Island, USA
  1. Correspondence to Yu-Qing Huang, Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Academy of Medical Sciences, Guangzhou 510080, China; hyq513{at}126.com

Abstract

Background Mean arterial pressure (MAP) is a predictor of all-cause and cardiovascular disease (CVD) mortality in middle-aged population and elderly, but less evidence has been shown in young adults.

Objectives We examined the associations of MAP with all-cause and CVD mortality in young adults aged between 18 and 40 years.

Methods Data were from the National Health and Nutrition Examination Survey (1999–2006) and participants were followed up to 31 December 2015. MAP was categorised by quartiles. Multivariable Cox proportional hazards models and Kaplan-Meier survival curves were performed to estimate the association between MAP, all-cause and CVD mortality.

Results There were a total of 8356 (4598 women (55.03%)) participants with the mean age of 26.63±7.01 years, of which 265 (3.17%) and 10 (0.12%) cases of all-cause and cardiovascular mortality occurred during a median follow-up duration of 152.96±30.45 months, respectively. There was no significant difference in the survival rate by MAP quartiles (p=0.058). When MAP was treated as a continuous variable, the multivariable adjusted HRs for all-cause and CVD mortality were 1.00 (95% CI 0.96 to 1.04; p=0.910) and 0.94 (95% CI 0.77 to 1.14; p=0.529), respectively. When using the lowest quartile (Q1) as referent, the adjusted HRs for all-cause mortality from Q2 to Q4 were 1.16 (95% CI 0.56 to 2.42), 1.06 (95% CI 0.48 to 2.32) and 0.91 (95% CI 0.37 to 2.24; p for tend was 0.749) after adjusting for potential confounders.

Conclusion There was no significant association of MAP with all-cause and CVD mortality in young adults with a relatively short follow-up time.

  • hypertension
  • risk management
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Footnotes

  • Contributors Y-lZ and Y-QH designed the study. SS and Y-QH drafted the manuscript. LL and KL analysed the data. JH, YQF and SS checked the collected data. KL, YQF and JH edited and revised the manuscript. The final manuscript was read and approved by all authors.

  • Funding During analysing data and submission of manuscript, this work was supported by the Science and Technology Program of Guangdong Province (No. 2017B030314041), the Science and Technology Program of Guangzhou (No. 201604020143, No. 201604020018, No. 201604020186, and No. 201803040012), and the National Key Research and Development Program of China (No. 2017YFC1307603, No. 2016YFC1301305) and the Key Area R&D Program of Guangdong Province (No. 2019B020227005).

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval The survey protocol was approved by the Institutional Review Board of the Centers for Disease Control and Prevention (Protocol #98-12 and Protocol #2005-06). All participants gave written informed consent.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Data availability statement Data are available in a public, open access repository. Data Availability in https://wwwn.cdc.gov/nchs/nhanes/Default.aspx.

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