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Hypoxia-inducible factors: new strategies for treatment of obesity-induced metabolic diseases
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  • Published on:
    HIF isoforms and personlized anti-obesity strategies ?
    • Farwa Munir, Doctor of Nutrition Faculty of Medicine, Universiti Sultan Zainal Abidin
    • Other Contributors:
      • Atif Baig, Molecular Geneticist

    Dear Editor,

    We have read the respective article entitled “overview of the possible treatment of hypoxia-induced obesity” by Sung Sik Choe and Jae Bum Kim(1). We were pleased to see how concisely they have linked hypoxia and hypoxia inducible factors with obesity. We agree to their problem statement, the gap analysis and the qualitative narrative review they have done to explain the process of inflammatory obesity.
    Hypoxia is defined as a state in which the tissue oxygen levels are less than normal. The range of normal oxygen levels in tissue is 3% to 9% (2). A stable transcription factor is activated in a hypoxic state, known as the Hypoxia-inducible factor (HIF). Hypoxia inducible factor has a greater role in stabilizing oxygen levels by increasing circulating hemoglobin (3). It is a heterodimeric transcription factor as per its structure, further divided into alpha and beta subunits. In inflammatory induced obesity, the alpha subunit is found to have a prominent role. Hypoxia-inducible factor a is further divided into two units, HIF 1a and HIF 2a (4). These two units play an antagonistic role. HIF 1a plays a significant role in increasing inflammation in adipose tissues leading to an increase in the risk of inflammatory obesity. As per the location of the HIF 1A gene, it is mapped and located on human chromosome 14q21-24. It codes for the transcription factor HIF 1a, an essential factor for systemic oxygen homeostasis. Higher HIF 1a can indicate squamous ce...

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    Conflict of Interest:
    None declared.