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Prognostic significance of LINC00460 overexpression in solid tumours: a meta-analysis
  1. Chen Dai1,
  2. Yan Zhang2,
  3. Hao Ni3,
  4. Yuting Kuang1,
  5. Zhihua Xu1
  1. 1 General Surgery, First Affiliated Hospital of Soochow University, Suzhou, China
  2. 2 Oncology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
  3. 3 Pathology, First Affiliated Hospital of Soochow University, Suzhou, China
  1. Correspondence to Dr Zhihua Xu, General Surgery, First Affiliated Hospital of Soochow University, Suzhou 215006, China; dr_zhihuaxu{at}; Dr Yuting Kuang, First Affiliated Hospital of Soochow University, Suzhou, China; doushidada{at}


The prognostic value of long intergenic non-protein coding RNA 460 (LINC00460) overexpression in human solid malignant tumours remains unclear. Therefore, we conducted the meta-analysis to systematically review and assess the evidence for the correlation between LINC00460 overexpression and clinicopathological features and overall survival (OS) of patients with solid malignant tumour. An electronic search of PubMed, EMBASE, Web of Science, CNKI, Cochrane Library, Chinese Biological Medical Literature database and WanFang database was applied to select eligible articles. Pooled ORs or HRs with their 95% CIs were calculated to estimate the effects. 9 eligible studies with a total of 935 patients were enrolled in this meta-analysis. The results revealed that high LINC00460 expression was associated with positive lymph node metastasis (positive vs negative: OR=2.97, 95% CI 1.74 to 5.05, p=0.812), advanced tumour-node-metastasis stage (III+IV vs I+II: OR=2.82, 95% CI 1.64 to 4.85, p=0.193) and poorer differentiation (high vs low: OR=0.60, 95% CI 0.36 to 0.99, p=0.569). Additionally, the overexpression of LINC00460 could predict a poorer OS (HR=1.57, 95% CI 1.39 to 1.77) and the shorter disease-free survival (HR=2.32, 95% CI 1.25 to 4.31). Furthermore, according to subgroup analysis and meta-regression results, the heterogeneity of current meta-analysis may be attributed to the differences of cancer type and follow-up months. High expression of LINC00460 could predict poor prognosis in patients with solid malignant tumour. LINC00460 may serve as potential prognostic biomarker for clinical outcomes in various human solid malignant tumours.

  • LINC00460
  • human solid malignant tumor
  • clinicopathological feature
  • prognosis
  • meta-analysis

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  • CD, YZ and HN are joint first authors.

  • Contributors CD and ZX drafted the work and assessed the included studies. The data were extracted from the included studies by two reviewers (ZX and YZ). All authors did the final approval of the version to be published and agreed to be accountable for all aspects of the work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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