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Proton pump inhibitors therapy has been found to be associated with some comorbidities.1 Recently, one case-control study disclosed a positive association between tuberculosis and proton pump inhibitors therapy (OR=1.13; 95% CI 1.10 to 1.28),2 which was compatible with another case-control study in Taiwan (OR=1.31; 95% CI 1.22 to 1.41).3 Some points need to be discussed. Proton pump inhibitors and histamine-2 receptor antagonists have similar indications for acid-related gastrointestinal diseases, but little research explores the association between the risk of tuberculosis and histamine-2 receptor antagonists therapy. In order to explore this issue, a preliminary case-control study was conducted …
Contributors S-WL contributed to the conception of the article, initiated the draft of the article and has approved the final draft submitted. C-LL and K-FL conducted data analysis.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval Insurance reimbursement claims data used in this study were available for public access. Patient identification numbers were scrambled to ensure confidentiality. This study was approved by the Research Ethics Committee of China Medical University and Hospital in Taiwan (CMUH-104-REC2-115).
Provenance and peer review Not commissioned; externally peer reviewed.