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Re-claiming H&E: back to the future
  1. Luis Alberto Romano,
  2. Viirginia Fonseca Pedrosa
  1. Universidade Federal do Rio Grande, Rio Grande, Brazil
  1. Correspondence to Professor Luis Alberto Romano, Universidade Federal do Rio Grande, Rio Grande 96210-030, Brazil; dcluis{at}

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Dear Editor,

In this note, we try to rescue the value of the H&E stain technique, used in routine practices, despite numerous repeated attempts in the literature to denigrate and ban it. In our opinion, there is no other technique in the vast profusion of human and veterinary medicine practices which provides as much information as quickly and at such low cost as the technique of H&E. To sustain this statement, we cite two examples of thyroid carcinomas, in which the simple recognition of microscopic tissue sections stained with H&E in two different varieties allowed to establish the biological behaviour of the tumours and the prognosis of the patients.1

However, when analysing the reasons for the attempts to discredit the technique in question, we should reflect on what grounds it is based, below appearances, once the technique of H&E is not difficult to be conducted.2 Years of observation of thousands of preparations are necessary …

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  • Funding This study was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico(301245?2016-9).

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Author note This letter describes the validity of the technique of H&E stain versus the new technology in the area of pathology.

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