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Renal salt wasting in Guillain-Barré syndrome
  1. Mritunjai Kumar1,
  2. Jayantee Kalita2,
  3. Usha Kant Misra2
  1. 1 Neurology, AIIMS Raipur, Raipur, India
  2. 2 Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
  1. Correspondence to Dr Jayantee Kalita, Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 22601, India; jayanteek{at}

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The syndrome of inappropriate antidiuretic hormone (SIADH) and cerebral salt wasting (CSW) are two well-defined entities associated with hyponatremia in patients with intracranial disease. CSW is defined as renal loss of sodium due to intracranial diseases leading to hyponatremia, excessive natriuresis and volume depletion, which responds to volume and salt replacement.1 Similar phenomenon has also been reported in patients without underlying central nervous system (CNS) disease, which has been termed as renal salt wasting (RSW).2 Autonomic dysfunction is common in Guillain-Barré syndrome (GBS) especially in those needing mechanical ventilation. There is only few case reports of RSW in GBS.3 4 Presence of RSW in GBS may adversely affect in cardiovascular stability and outcome. It is therefore important to recognise this clinical entity and manage appropriately. We report six GBS patients with RSW, and describe their clinical and neurophysiological characteristics and outcome.

Six GBS patients with RSW were included prospectively. GBS was diagnosed based on clinical, cerebrospinal fluid and neurophysiological criteria. Both admission and peak disability was noted using a 0–10 Clinical Grading Scale (CGS). Autonomic dysfunction was defined by the presence of any of the following: sinus arrhythmia, resting tachycardia (heart rate >125/ min) or bradycardia (<48/min), …

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  • Contributors MK: data collection, follow-up, data interpretation, literature search, construction of figures and writing the manuscript. JK: involved in study supervision, data interpretation and writing the manuscript. UKM: involved in data interpretation and writing the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study was approved by Institutional Ethics Committee (PGI/BE/818/2015, IEC code: 2015-131-IP-88), SGPGIMS, Lucknow, India.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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