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Cushing’s response and Cushing’s ulcer
  1. Charlotte E Griffiths1,
  2. Amit K J Mandal1,
  3. Constantinos G Missouris1,2
  1. 1 Departments of Cardiology and Internal Medicine, Frimley Health NHS Foundation Trust, Wexham Park Hospital, Slough, Berkshire, UK
  2. 2 Clinical Cardiology, University of Cyprus Medical School, Nicosia, Cyprus
  1. Correspondence to Professor Constantinos G Missouris, Frimley Health NHS Foundation Trust, Wexham Park Hospital, Slough GU16 7UJ, UK; dinos.missouris{at}

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A 57-year-old man presented to our service with a 4-month history of clumsiness, unsteady gait and progressive bilateral sensorineural hypoacusia. Neurological examination revealed symmetrical weakness in the lower limbs (power 4/5) with brisk deep tendon reflexes and upgoing plantars.

During initial assessment, there was massive haematemesis but a paradoxical physiological response to intravascular depletion with systolic blood pressure not falling below 160 mm Hg and episodes of sinus bradycardia on telemetry with heart rates ranging from 20 to 40 beats/min, lasting up to 10 s. While bradycardic, he became unresponsive (Glasgow Coma …

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  • Contributors CEG conceived the study, performed the literature search, and wrote and edited the manuscript up to submission. AKJM edited the manuscript up to submission and performed the literature search. CGM oversaw the project and wrote and edited the manuscript up to submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Consent obtained from next of kin.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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