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Giant plexiform neurofibroma of thigh in a young woman
  1. Shuzhong Liu1,
  2. Xi Zhou1,
  3. An Song2,
  4. Zhen Huo3,
  5. Yipeng Wang1,
  6. Yong Liu
  1. 1 Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
  2. 2 Key Laboratory of Endocrinology, Department of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
  3. 3 Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
  1. Correspondence to Professor Yong Liu, Department of Orthopedic Surgery, Peking Union Medical College Hospital, Beijing 100730, China; liuyong_pumch{at}163.com

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A 30-year-old woman presented to orthopaedic clinic with a 5-year history of severe pain and oedema of left lower limb. The patient denied experiencing any other constitutional symptoms and no history of trauma or surgery during the past years. Physical examination revealed multiple longitudinal tumours on the back of both thighs, with a maximum diameter of about 5 cm on the left side. The patient showed pressure pain and percussion pain in bilateral lower limbs, decreased sensation to pinprick and fine touch sensation of left lower extremity and exhibited a 5/5 strength in the left lower limb. Ultrasonography revealed several hypoechoic masses along the sciatic nerve in the soft tissue of bilateral lower limbs, which were beaded and varied in size. Moreover, the tibial nerve was involved on the left side from the outlet of piriformis muscle to the upper shin. The length of the lesion on the left side was about 53 cm, and the width was about …

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Footnotes

  • Contributors SL wrote the first draft of the manuscript and submitted the manuscript. XZ, AS and ZH were in charge of the patient and collected the data. SL and YL did the follow-up of the patient. YW and YL critically revised the manuscript and contributed equally to this paper. All authors approved the final version.

  • Funding This study was funded by the National Natural Science Foundation of China, http://dx.doi.org/10.13039/501100001809 (Project No 81871746) and Peking Union Medical College Graduate Student Innovation Fund (Project No 2018-1002-02-08).

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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