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- interstitial lung disease
- common variable immunodeficiency (cvid)
- granulomatous and lymphocytic interstitial lung disease (glild)
A middle-aged woman with common variable immunodeficiency (CVID) presented with progressive dyspnoea and fevers. She had a temperature of 38.9°C, oxygen saturation of 91% on room air and decreased breath sounds at the lung bases. Her lab showed pancytopaenia. Chest CT revealed diffuse ground-glass opacities, hilar and mediastinal lymphadenopathy, and right lower lobe consolidation (figure 1). She received empiric broad-spectrum antibiotics without improvement. An infectious work-up and lymph node biopsy were unremarkable. Bronchoscopy with transbronchial biopsy showed dense bronchial wall lymphoid infiltrates with non-caseating granulomas (figure 2). Bacterial, mycobacterial, fungal and …
Contributors All authors participated in the preparation of the manuscript. JAS and AN planned the write-up. JAS wrote the manuscript. AN and RKC helped edit the manuscript. RKC provided the pathology images and figure legends.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.