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TnI and IL-18 levels are associated with prognosis of sepsis
  1. Qinghua Wu1,
  2. Zhaoyang Xiao2,
  3. Yanan Pu2,
  4. Jianwen Zhou1,
  5. Dehuai Wang1,
  6. Zhiyong Huang1,
  7. Dongnan Hou2
  1. 1 Departm​ent of burn and plastic surgery, The Second People’s Hospital of Chengdu, Chengdu, China
  2. 2 Department of Anesthesiology, The Second Affiliated Hospital, Dalian Medical University, Dalian, China
  1. Correspondence to Dr Dongnan Hou, Department of Anesthesiology, The Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China; dongnanhouyx{at}


Aim To evaluate the diagnostic value of interleukin-18 (IL-18) and troponin (TnI) in sepsis.

Methods This retrospective analysis included 117 patients with sepsis (patient group) and 92 subjects who attended regular physical examinations (control group). We compared IL-18 and TnI expressions before treatment (T1) and on day 5 (T2), day 10 (T3) and day 15 (T4) of treatment. Acute Physiology and Chronic Health Evaluation II (APACHE II) guidelines were used to analyse the correlation between IL-18, TnI and APACHE II scores.

Results At T1, T2, T3 and T4, the IL-18 and TnI levels were all higher in the patient group than in the control group (p<0.001). In the patient group, peak IL-18 and TnI levels were noted at T1, followed by T2, T3 and T4 (p<0.001). The linear correlation analysis revealed positive correlations between IL-18 and TnI levels and APACHE II score (r =0.759, 0.866, p <0.001). The 3-year survival rates of subjects with high IL-18 or TnI expression levels were all lower than of those with low expression levels (p=0.047, 0.048). In patients with sepsis, the expression of TnI and IL-18 is high and is positively correlated with APACHE II scores.

Conclusions Monitoring TnI and IL-18 levels can effectively evaluate the severity and recovery of patients with sepsis.

  • sepsis
  • tni
  • IL-18
  • prognosis
  • survival rate
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  • Contributors QW, ZX and ZH conceived the project, and designed and performed the experiments. YP and JZ analysed the data. DW and DH wrote the manuscript.DH and QW revised the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study received approval from The Second Affiliated Hospital, Dalian Medical University’s ethics committee. All study participants had given their written informed consent before participating in the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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