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Convulsive seizures caused by metronidazole-induced encephalopathy
  1. Tatsuya Ueno,
  2. Masako Ito,
  3. Akira Arai,
  4. Chieko Suzuki,
  5. Masahiko Tomiyama
  1. Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan
  1. Correspondence to Dr Tatsuya Ueno, Neurology, Aomori Prefectural Central Hospital, Aomori 030-8553, Japan; tatsuya_ueno{at}

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A 60-year-old Japanese man who had been treated with metronidazole (1000 mg/day) for splenic abscesses diagnosed 85 days earlier was transferred to our department because of convulsive seizures and impaired consciousness. He did not consume alcohol and his medical history included the treatment of rheumatoid arthritis with prednisolone and iguratimod for the past 6 years. On admission, his Glasgow Coma Scale score was E4V4M6 and his body temperature was 36.8°C. Neurological …

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  • Contributors TU wrote the manuscript. TU, MI, AA, CS and MT were involved in patient management and collection of data. TU, MI, AA, CS and MT edited and approved the final manuscript.

  • Funding The authors did not receive government research grants to carry out the present study nor they did receive any funding from the commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.