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Despite the fact that sodium glucose cotransporter 2 inhibitors (SGLT2-i) have proven efficacy in controlling hyperglycaemia and reducing cardiovascular outcomes, their adverse effects on the urogenital tract remain a concern.1 We report a patient with acute unilateral emphysematous pyelonephritis possibly associated with canagliflozin.
A 59-year-old woman presented to the emergency department with high-grade fever with chills and rigours for 1 day. She also complained of painful micturition and dull pain in flanks. She was known to have diabetes for 14 years, and her antihyperglycaemic medications included gliclazide 80 mg daily, linagliptin 5 mg daily, metformin 1 g daily and canagliflozin 100 mg daily. Notably, canagliflozin had been started about 11 months before …
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