Purpose of the study The aim of this study was to perform a meta-analysis to derive precise estimation of the association of interleukin-23 receptor (IL-23R), IL-1 receptor 2 (IL-1R2), IL-12 beta (IL-12B), IL-10 and tumour necrosis factor (TNF)-α polymorphisms with ankylosing spondylitis (AS) susceptibility.
Study design A systematic literature search was conducted to identify the relevant studies. Pooled OR with 95% CI was calculated to assess the strength of the association in a fixed or random-effects model.
Results A total of 13 917 cases and 19 849 controls in 43 eligible studies were included in the meta-analysis. Seventeen single-nucleotide polymorphisms (SNPs) in the abovementioned five cytokine genes were evaluated. The results indicate that the nine SNPs (rs11209026, rs1004819, rs10489629, rs11465804, rs1343151, rs11209032, rs1495965, rs7517847, rs2201841) of IL-23R are associated with AS susceptibility in all study subjects in the allelic model. Moreover, stratification by ethnicity identified a significant association between seven SNPs of IL-23R and AS susceptibility in Europeans and Americans, but not in Asians. In addition, the IL-10–819 C/T and TNF-α−857 C/T polymorphisms also confer susceptibility to AS, especially in Asian population.
Conclusion The results suggested that the genetic susceptibility for AS is associated with the nine SNPs of IL-23R in overall population. In the subgroup analysis, significant associations were shown in European and American population, but not in Asian population. Our results also suggest that IL-10–819 C/T and TNF-α−857 C/T polymorphism might be associated with AS risk, especially in Asian population.
- ankylosing spondylitis
- tumor necrosis factor
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YX and YL contributed equally.
Contributors Study design and the writing of the manuscript: YX, YL and GPW. Data collection, preparation and analysis: SG, JGY and MST, manuscript revision and final language editing: PHX and FDQ. Guarantor: GPW.
Funding The Humanities and Social Science Research Project of Anhui (SK2018A0202). The Provincial Quality Engineering Project of Anhui (2014zy046).
Competing interests None declared.
Patient consent Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
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