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Lung cancer in lung transplantation: incidence and outcome
  1. David Pérez-Callejo1,
  2. María Torrente1,
  3. Consuelo Parejo1,
  4. Rosalia Laporta2,
  5. Piedad Ussetti2,
  6. Mariano Provencio1
  1. 1 Department of Medical Oncology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain
  2. 2 Department of Pulmonology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain
  1. Correspondence to Dr David Pérez-Callejo, Servicio de Oncolog­ía Médica, Hospital Universitario Puerta de Hierro-Majadahonda, Calle Manuel de Falla, Madrid 28222, Spain; davidperezc{at}


Introduction Malignancies are one of the causes of mortality after lung transplantation. However, little is known about lung cancer outcome after lung transplantation.

Methods We performed a retrospective search of the lung transplantation database at our institution to identify patients diagnosed with lung cancer after lung transplantation.

Results Out of 633 lung transplant patients, lung cancer was detected in 23 of them (3.63%). The most common causes for transplantation were idiopathic pulmonary fibrosis (47.8%) and emphysema (43.4%). A total of 18 patients were diagnosed during follow-up, 12 cases in the native lung (52.2%) and 6 cases in the donor lung (26.1%). The diagnosis was evidenced in the explanted lung in five patients (21.7%). The median of time from transplantation to cancer diagnosis was 39.7 months (24.356.6). Lung cancer was the cause of death in 16 patients. Survival rate at1year from diagnosis of lung cancer was 45.64% (95% CI 0.2431 to 0.6473).

Conclusions Lung transplant recipients constitute a high-risk group for developing lung cancer. Among our patients, lung cancer was predominantly diagnosed in the native lung and at an advanced stage. The primary tumour was the main cause of death in most of these patients.

  • lung transplantation
  • lung cancer
  • idiopathic pulmonary fibrosis
  • emphysema

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  • Contributors All authors have contributed to conception and design, acquisition of data, analysis and interpretation of data, drafting the article, and final approval of the last version.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Puerta de Hierro Hospital Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.