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Minocycline-induced skin hyperpigmentation
  1. Jonathan D Alpern, Corresponding author1,
  2. Anjum Kaka2
  1. 1 Division of Infectious Disease and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
  2. 2 Division of Infectious Disease, Department of Medicine, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
  1. Correspondence to Dr Jonathan D Alpern, 420 Delaware Street SE, MMC 250 Mayo, Minneapolis, MN 55455, USA; alper054{at}

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A 67-year-old male with rheumatoid arthritis and recurrent left prosthetic knee infection due to methicillin-resistant Staphylococcus aureus presented to the clinic. He had been taking minocycline 100 mg orally twice a day for the previous 16 months as chronic suppressive therapy. On physical examination, multiple new bluish-grey macules and patches were seen on bilateral forearms and legs (figures 1 and 2). We diagnosed the patient with an unusually severe form of type II minocycline-induced hyperpigmentation. The patient was not on any other medications known …

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  • Contributors All authors have seen this manuscript, contributed significantly to the manuscript and agree with its submission to this journal.

  • Competing interests None declared.

  • Provenance and peer review This article has been corrected since it was published Online First. The first author's name has been corrected.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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