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Neurosarcoidosis: unusual presentations and considerations for diagnosis and management
  1. Walid Radwan1,
  2. Brandon Lucke-Wold2,
  3. Ibrahim Ahmed Robadi3,
  4. Kymberly Gyure3,
  5. Thomas Roberts4,
  6. Sanjay Bhatia1
  1. 1Department of Neurosurgery, West Virginia University, Morgantown, West Virginia, USA
  2. 2West Virginia University, Morgantown, West Virginia, USA
  3. 3Department of Pathology, West Virginia University, Morgantown, West Virginia, USA
  4. 4Department of Radiology, West Virginia University, Morgantown, West Virginia, USA
  1. Correspondence to Dr Walid Radwan, Department of Neurosurgery, West Virginia University School of Medicine, One Medical Center Drive, Suite 4300, Health Sciences Center, Morgantown, WV 26505, USA; walid.radwan{at}


Background Sarcoidosis is a chronic, multisystem disease characterised by non-necrotising granulomatous inflammation of unknown aetiology. Most commonly, the lungs, lymph nodes, skin and eyes are affected in sarcoidosis; however, nervous system involvement occurs in approximately 5%–15% of cases. Any part of the nervous system can be affected by sarcoidosis.

Cases Herein we describe three unusual patient presentations of neurosarcoidosis, one with optic neuritis, a second with hydrocephalus and a third with cervical myelopathy.

Conclusions We include pertinent details about their presentations, imaging findings, pathology, management and clinical course.

  • neurosarcoidosis
  • optic neuritis
  • hydrocephalus

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  • Contributors WR and BL has made substantial contributions to the conception or design of the work or the acquisition, analysis or interpretation of data for the work; drafted the work or revised it critically for important intellectual content. All authors included approve the final version to be published and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.