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Association and interaction analysis of diabetes mellitus and SCN10A for cardiovascular autonomic neuropathy in a Chinese population
  1. Yubao Lv1,2,
  2. Linuo Zhou3,
  3. Zihui Tang1,2,
  4. Jingcheng Dong1,2
  1. 1Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China
  2. 2Institutes of Integrative Medicine, Fudan University, Shanghai, China
  3. 3Institution of Diabetology, Fudan University, Shanghai, China
  1. Correspondence to Dr Zihui Tang, Department of Integrative Medicine, Huashan Hospital, Institutes of Integrative Medicine, Fudan University, No. 12 Urumqi Middle Road, Shanghai 200040, China; dr_zhtang{at}


Background This study assessed the extent to which diabetes mellitus (DM) and SCN10A (rs7375036) and their interaction impact on cardiovascular autonomic neuropathy (CAN) susceptibility in a Chinese Han sample.

Method We performed a study in a cross-sectional dataset that included 419 patients with DM and 1557 controls who were genotyped for the presence of the SCN10A rs7375036 polymorphisms. Genotyping was performed by iPLEX technology. The associations of rs7375036 and DM with CAN was assessed by using univariate and multivariate logistic regression controlling for confounders. The interaction between rs7375036 and DM for CAN susceptibility on an additive scale was calculated by using the relative excess risk due to interaction (RERI), the proportion attributable to interaction (AP), and the synergy index (S).

Results The univariate logistic analyses failed to show an association between the SCN10A rs7375036 polymorphisms and CAN. Interestingly, a novel interaction effect of SCN10A rs7375036 and DM on CAN was assessed (p=0.055; RERI=3.515, 95% CI 1.829 to 5.805; AP=0.632, 95% CI −0.368 to 1.632; S=4.361, 95% CI 2.071 to 9.184).

Conclusions Our findings suggest that there are interaction effects of DM and SCN10A (rs7375036) that influence the development of CAN.

Trial registration number NCT02461342

  • SCN10A
  • cardiovascular autonomic neuropathy
  • interaction
  • Diabetes Mellitus
  • Chinese population

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  • Contributors YL drafted the manuscript; LZ participated in the design of the study and performed the statistical analysis; ZT and JD conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.

  • Funding Grants from the Clinical Medicine Foundation of Huashan Hospital.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Ethics Committee of Huashan Hospital and Shanghai Tongji Hospital, Shanghai, China (reference number: TJH-2015-017).

  • Provenance and peer review Not commissioned; externally peer reviewed.