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A case of severe leg oedema in a patient with Parkinson's disease treated with pramipexole
  1. C Edoardo Cicero,
  2. Alessandra Nicoletti,
  3. Giovanni Mostile,
  4. Mario Zappia
  1. Dipartimento G.F. Ingrassia, Sezione di Neuroscienze, Università Degli Studi di Catania, Catania, Italy
  1. Correspondence to Professor Mario Zappia, Department G.F. Ingrassia, Section of Neurosciences, University of Catania, Via Santa Sofia 78, Catania 95123, Italy; m.zappia{at}

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Case report

A 57-year-old man with a diagnosis of Parkinson's disease (PD) was admitted to our clinic because in the last 2 years he experienced worsening of his parkinsonian symptoms, especially gait difficulties that recently led him to fall and report head trauma and fracture of the left wrist. He had been diagnosed with parkinsonism 8 years before and had been treated with levodopa and dopamine agonists with a good motor response. Three years ago, because of worsening of his motor condition, therapy with pramipexole 2.1 mg prolonged release was started in association with levodopa/carbidopa 200/50 mg sustained release TID without a satisfactory motor response. …

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  • Contributors CEC and GM were involved in the development of the paper concept and design, acquisition of data, analysis and interpretation, and critical revision of the literature. AN and MZ were responsible for interpretation of data and revision of the paper.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.