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A 57-year-old man with a diagnosis of Parkinson's disease (PD) was admitted to our clinic because in the last 2 years he experienced worsening of his parkinsonian symptoms, especially gait difficulties that recently led him to fall and report head trauma and fracture of the left wrist. He had been diagnosed with parkinsonism 8 years before and had been treated with levodopa and dopamine agonists with a good motor response. Three years ago, because of worsening of his motor condition, therapy with pramipexole 2.1 mg prolonged release was started in association with levodopa/carbidopa 200/50 mg sustained release TID without a satisfactory motor response. …
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