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Minocycline-induced pigmentation of the skin and nails
  1. Faisal R Ali,
  2. Zenas ZN Yiu,
  3. Stephanie Ogden
  1. Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester, UK
  1. Correspondence to Dr Zenas ZN Yiu, Dermatology Centre, Salford Royal NHS Foundation Trust, Stott Lane, Manchester M6 8HD, UK; zenas.yiu{at}

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Minocycline is an effective treatment for inflammatory cutaneous conditions, such as acne vulgaris and rosacea, infectious conditions and has recently been investigated for its neuroprotective properties. However, treatment with minocycline can induce iatrogenic pigmentation, affecting both the skin and other organs. Recognition of these changes may avoid unnecessary investigations. This image case report aims to remind clinicians of this often-persistent side effect of minocycline.


A 73-year-old man attended the dermatology outpatient clinic with a 20-year history of progressive swelling of the nose, associated with red papules and pustules on both cheeks. He had a background of hypertension, and is on lisinopril and simvastatin. He was diagnosed with rosacea and …

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  • Contributors All authors contributed to the case management and review and drafting of the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.