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Metformin: safety in cardiac patients
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  • Published on: 27 July 2010
    Re:Metformin concerns

    Sir,

    With great interest I read the article on Metformin: safety in cardiac patients, by R Khurana, and I S Malik.

    It might be worthwhile pointing out that long term use of metformine can be the cause of neuropathy due to a chronic difficiency of vitamine B12. Long-term use of metformin is associated with malabsorption of vitamin B(12) (cobalamin). This might in turn have a deleterious effects on the...

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    Conflict of Interest:
    None declared.
  • Published on: 17 June 2010
    Metformin concerns

    Dear Editor,

    The review on metformin safety summarizes cogently the current clinical approach on the use of metformin in special situations (1).

    The picture may be less clear as the drug is also an inhibitor of mitochondrial complex I (2), and oxygen consumption may thus be impaired (3).

    It should be remembered that metformin also increases D-lactate formation, an end metabolite of methylglyo...

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    Conflict of Interest:
    None declared.