Article Text

Download PDFPDF
Preventing type 2 diabetes: can we make the evidence work?
  1. T Yates1,
  2. M Davies1,
  3. K Khunti2
  1. 1
    Department of Cardiovascular Sciences, University of Leicester, UK
  2. 2
    Department of Health Sciences, University of Leicester, UK
  1. Correspondence to Dr T Yates, Diabetes Research Unit, Level 1 Victoria Building, Leicester Royal Infirmary, Leicester LE1 5WW, UK; ty20{at}


Type 2 diabetes is associated with many serious comorbidities and is one of the leading causes of mortality globally. Type 2 diabetes is preceded by a condition called prediabetes, which is characterised by elevated glucose concentrations resulting from peripheral and/or hepatic insulin resistance. Individuals with prediabetes have been the traditional target of diabetes prevention programmes; these have consistently shown that lifestyle modification can significantly reduce the risk of developing type 2 diabetes. This has led to the implementation of diabetes prevention initiatives in several countries. However, a number of key areas still need to be addressed. For example, important questions remain regarding how best to identify at-risk individuals and whether the findings from resource intensive research projects can be replicated using pragmatic lifestyle interventions tailored to the resources and infrastructure available to usual health care practice. This article highlights findings from diabetes prevention programmes and discusses key issues involved in translating research into practice.

  • type 2 diabetes
  • endocrinology
  • preventive medicine

Statistics from


  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.