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The added value of peripheral blood cell morphology in the diagnosis and management of infectious diseases—part 1: basic concepts
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  • Published on:
    disseminated intravascular coagulation may be a clue to disseminated tuberculosis

    Abnormalities in peripheral blood morphology which are indicative of underlying infection include stigmata of disseminated intravascular coagulation(DIC), exemplified by the presence of schistocytes and fragmented red blood attributable to red blood cell trapping and damage within fibrin thrombi(1). Accordingly, the added value of peripheral blood cell morphology in the diagnosis of infectious diseases(2) includes recogn...

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    Conflict of Interest:
    None declared.
  • Published on:
    Authors reply
    • Miron Prokocimer, Professor in Hematology MD
    • Other Contributors:
      • Israel Potasman

    16/2/09

    To the Editor

    The additional examples detailed above regarding TB-associated DIC and HIV/AIDS-associated splenic hypofunction are indeed noteworthy. The association with AIDS appears to be complex and multi-factorial, attributable not only to the effects of HIV(1) and/or various opportunistic infections on the immunologic function of the spleen (e.g Mycobacterium avium comlex as mentioned, and...

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    Conflict of Interest:
    None declared.