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Adverse drug reaction
Rhabdomyolysis with atorvastatin and fusidic acid
  1. C O’Mahony1,
  2. V L Campbell2,
  3. M S Al-Khayatt3,
  4. D J Brull1
  1. 1
    The Heart Hospital, London, UK
  2. 2
    Royal Surrey County Hospital, Guildford, Surrey, UK
  3. 3
    Department of Neurophysiology, Whittington Hospital, London, UK
  1. Dr C O’Mahony, The Heart Hospital, 16–18 Westmoreland Street, London W1G 8PH, UK; c.omahony{at}doctors.org.uk

Abstract

Rhabdomyolysis is a rare but life-threatening complication of statin therapy. A 74-year-old man, treated with atorvastatin, developed rhabdomyolysis after the co-administration of fusidic acid and flucloxacillin. The patient recovered with supportive treatment and subsequently tolerated reintroduction of atorvastatin. Pharmacokinetic interactions can cause raised plasma statin concentrations, which can precipitate rhabdomyolysis in the presence of certain predisposing biological factors.

  • rhabdomyolysis
  • fusidic acid
  • flucloxacillin
  • atorvastatin
  • statins

http://dx.doi.org/10.1136/pgmj.2007.064097

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    Footnotes

    • Competing interests: None.

    • Patient consent: Informed patient consent was obtained for publication of the details in this report.

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    2008 The Fellowship of Postgraduate Medicine