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Drug interaction with anti-mycobacterial treatment as a cause of clopidogrel resistance
  1. M Srinivasan,
  2. D Smith
  1. Department of Cardiology, Morriston Hospital, Swansea, Wales, UK
  1. Dr M Srinivasan, Department of Cardiology, Morriston Hospital, Swansea SA 6 6NL, Wales, UK; smanivannan70{at}


The case is reported of a patient presenting with recurrent acute myocardial infarction due to stent thrombosis resulting from possible clopidogrel resistance caused by interaction between clopidogrel and anti-tuberculosis drugs. A brief overview of drug interaction as a risk factor for clopidogrel resistance is given.

  • anti-mycobacterial therapy
  • clopidogrel resistance
  • cytochrome 450 3a
  • dual anti-platelet therapy
  • stent thrombosis
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  • Competing interests: None declared.

  • Patient consent: Informed consent was obtained for publication of the person's details in this report.

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