Diabetes mellitus is responsible for a spectrum of cardiovascular disease. The best known complications arise from endothelial dysfunction, oxidation, inflammation, and vascular remodelling and contribute to atherogenesis. However, the effects on the heart also relate to concurrent hypertensive heart disease, as well as direct effects of diabetes on the myocardium. Diabetic heart disease, defined as myocardial disease in patients with diabetes that cannot be ascribed to hypertension, coronary artery disease, or other known cardiac disease, is reviewed.
- diabetes mellitus
- left ventricular function
- tissue characterisation
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Funding: This programme is supported in part by a Clinical Centre of Research Excellence award from the National Health and Medical Research Council of Australia.
Competing interests: None declared.
This is a reprint of a paper that appeared in Heart, March 2006, volume 92, pages 296–300. Reprinted with kind permission of the author and publisher.
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