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Massive cardiac invasion by amelanotic melanoma with obstructive clinical features
  1. S Dubrey1,
  2. R Grocott-Mason1,
  3. T Mittal2,
  4. M Burke3
  1. 1
    Department of Cardiology, Hillingdon Hospital, Uxbridge, Middlesex, UK
  2. 2
    Department of Medical Imaging, Harefield Hospital, Harefield, Middlesex, UK
  3. 3
    Department of Pathology, Harefield Hospital, Harefield, Middlesex, UK
  1. Dr S Dubrey, Department of Cardiology, Hillingdon Hospital, Pield Heath Road, Uxbridge, Middlesex UB8 3NN, UK; simon.dubrey{at}


Reports of malignant melanoma involving the heart usually describe metastatic spread of pigmented (melanotic) forms of this tumour. We describe, and illustrate, a patient presenting with features related to cardiac tamponade and intracardiac obstruction. Transthoracic echocardiography initially showed a large mass within the right ventricular outflow tract. The full extent of infiltration of this tumour was demonstrated by computed tomography scanning and the specific tumour type by immunohistochemical staining procedures. The case is unusual in relation to the extreme size of this amelanotic melanoma at presentation and the fact that it appears to be a solitary metastasis.

  • melanoma
  • echocardiogram
  • tamponade
  • CT

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  • Competing interests: None stated.

  • Patient consent: Informed consent was obtained for publication of the patient’s details in this report.