Total hip replacement represents the most significant advance in orthopaedic surgery in the 20th century. Periprosthetic osteolysis remains the most significant long-term complication with total hip replacement. It has been reported with all materials and prosthetic devices in use or that have been used to date. This paper reviews the current thinking on the aetiology, pathogenesis, management and future treatment options for osteolysis.
- BMPs, bone morphogenic proteins
- HA, hydroxyapatite
- MSCs, mesenchymal stem cells
- THR, total hip replacement
- UHMWPE, ultra-high-molecular-weight polyethylene
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Conflicts of interest: None
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