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How do you treat bleeding disorders with desmopressin?
  1. Bülent Özgönenel,
  2. Madhvi Rajpurkar,
  3. Jeanne M Lusher
  1. Carman and Ann Adam’s Department of Pediatrics, Division of Hematology/Oncology, Children’s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA
  1. Correspondence to:
 Dr Bülent Özgönenel
 Children’s Hospital of Michigan, Division of Hematology/Oncology, 3901 Beaubien Boulevard, Detroit, MI 48201-2196, USA; bulentozgonenel{at}


Desmopressin is an analog of vasopressin that exerts a substantial haemostatic effect by inducing the release of von Willebrand factor from its storage sites in endothelial cells. It has proved useful in treating or preventing bleeding episodes in patients with von Willebrand disease, haemophilia A and platelet function defects. Its efficacy in achieving a satisfactory level of haemostasis has reduced the use of blood products to treat bleeding episodes. Clinicians need to become familiar with the use of this drug that has become a home medication for many patients with inherited bleeding disorders.

  • FVIII, coagulation factor VIII
  • VWD, von Willebrand disease
  • VWF, von Willebrand factor
  • desmopressin
  • haemostasis
  • von Willebrand factor
  • blood coagulation disorder
  • drug therapy

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  • Competing interests: None.