Article Text
Adverse drug reaction
Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism
Abstract
A 54-year-old hypothyroid male taking thyroxine and simvastatin presented with bilateral leg compartment syndrome and myonecrosis. Urgent fasciotomies were performed and the patient made an uneventful recovery with the withdrawal of simvastatin. It is likely that this complication will be seen more often with the increased worldwide use of this drug and its approval for all arteriopathic patients.
- compartment syndrome
- hypothyroidism
- myonecrosis
- simvastatin
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Footnotes
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Competing interests: None.
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Informed consent was obtained for publication of the person’s details in this report.