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Mutation in the ATP7A gene may not be responsible for hypocupraemia in copper deficiency myelopathy
  1. N Kumar1,
  2. J B Gross, Jr2
  1. 1Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
  2. 2Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic
  1. Correspondence to:
 Dr N Kumar
 Department of Neurology, Mayo Clinic Bldg E-8 A, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA; kumar.neeraj{at}

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The identified causes of copper deficiency in patients with copper deficiency myelopathy have included excessive consumption of zinc, a malabsorption syndrome, or a history of gastric surgery.1 Not uncommonly the cause of copper deficiency has been unclear. We have recently reported on two patients with idiopathic hypocupraemic myelopathy who had increased copper content in biopsy specimens of the colonic mucosa.2 This finding suggests impaired mobilisation of copper absorbed by …

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