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Aetiology, diagnosis, and management of hypopituitarism in adult life
  1. V K B Prabhakar1,
  2. S M Shalet2
  1. 1Department of Diabetes and Endocrinology, Stepping Hill Hospital, Stockport, Cheshire, UK
  2. 2Christie Hospital, Manchester, UK
  1. Correspondence to:
 Dr V K B Prabhakar
 Department of Diabetes and Endocrinology, Lime House, Stepping Hill Hospital, Stockport, Cheshire SK2 7JE, UK; kaari_24{at}


Hypopituitarism is a complex medical condition associated with increased morbidity and mortality, requires complicated treatment regimens, and necessitates lifelong follow up by the endocrinologist. The causes, clinical features, and the management of hypopituitarism including endocrine replacement therapy are considered in this review article.

  • NFPA, non-functioning pituitary adenoma
  • PRL, prolactin
  • FSH, follicle stimulating hormone
  • LH, luteinising hormone
  • DI, diabetes insipidus
  • GH, growth hormone
  • ACTH, adrenocorticotrophic hormone
  • TSH, thyroid stimulating hormone
  • MPHD, multiple pituitary hormone deficiencies
  • MR, magnetic resonance
  • CSF, cerebrospinal fluid
  • BMD, bone mineral density
  • IGF1, insulin-like growth factor 1
  • GHD, growth hormone deficiency
  • AGHD, adult growth hormone deficiency
  • ITT, insulin tolerance test
  • GHRH, growth hormone releasing hormone
  • GST, glucagon stimulation test
  • HPA, hypothalamic-pituitary-adrenal
  • TRH, thyrotrophin releasing hormone
  • GnRH, gonadotrophin releasing hormone
  • HCG, human chorionic gonadotrophin
  • SMR, standardised mortality ratio
  • HRT, hormone replacement therapy
  • QoL, quality of life
  • HC, hydrocortisone
  • PSA, prostate specific antigen
  • hypopituitarism
  • growth hormone deficiency
  • pituitary hormone replacement therapy
  • endocrine replacement therapy

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  • Funding: none.

  • Competing interests: none declared.

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