Article Text

Download PDFPDF

A woman who couldn’t speak: report of methotrexate neurotoxicity
  1. P Szawarski1,
  2. C S Chapman2
  1. 1Respiratory Medicine, Glenfield General Hospital, Leicester, UK
  2. 2Haematology Department, Leicester Royal Infirmary, Leicester, UK
  1. Correspondence to:
 Dr C S Chapman
 Haematology Department, Sandringham Building, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK;


The association between methotrexate therapy and idiosyncratic neurological complications is well recognised in children. This case illustrates the importance of considering the diagnosis of methotrexate toxicity in an adult patient with behavioural and speech disturbances, who received it by intrathecal route only and in whom the only indicator was an abnormal electroencephalographic study

  • ALL, acute lymphoblastic leukaemia
  • MRI, magnetic resonance imaging
  • acute lymphoblastic leukaemia
  • aphasia
  • methotrexate

Statistics from


    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.