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Urinary tract infections: new insights into a common problem
  1. R Kucheria1,
  2. P Dasgupta1,
  3. S H Sacks2,
  4. M S Khan1,
  5. N S Sheerin2
  1. 1Department of Urology, Guy’s and St Thomas’ Hospital NHS Trust, London, UK
  2. 2Department of Renal Medicine and Transplantation, King’s College London, Guy’s Hospital
  1. Correspondence to:
 MrR Kucheria
 Department of Urology, 1st Floor Thomas Guy House, Guy’s Hospital, London SE1 9RT, UK;


This review discusses recent advances in the understanding of how the common pathogen, uropathogenic Escherichia coli, interacts with the host to lead to infection.

  • UTI, urinary tract infection
  • UPEC, uropathogenic Escherichia coli
  • LPS, lipopolysaccharide
  • CNF, cytotoxic necrotising factor
  • THP, Tamm-Horsfall protein
  • TLR, toll-like receptor
  • MAC, membrane attack complex
  • vaccine
  • urinary tract infections
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  • Funding: Wellcome Trust (Neil S Sheerin).

  • Conflicts of interest: none declared.

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