Responses
Other responses
Jump to comment:
- Published on: 14 September 2004
- Published on: 8 September 2004
- Published on: 25 August 2004
- Published on: 14 September 2004Re: Alas, Alas, Animal Models!Show More
Editor
There is a very sad account of the fatal consequences of extrapolation of animal findings to humans, "recent experience with fialuridin ... five out of 15 patients died, two required emergency liver and kidney transplant for liver and kidney failure-this effect had not been demonstrated in four animal species."[1] This is a very sobering account of the consequences of extrapolating animal findings to humans....
Conflict of Interest:
None declared. - Published on: 8 September 2004Alas, Alas, Animal Models!Show More
Dear Editor
Jackson raises a point that is indeed relevant, and I fully agree that premature extrapolations to human therapeutics are dangerous.[1] If animals were all horses, wishes would fly! These animal studies only provide a glimpse into new possibilities and futuristic ideas. I am concerned about any other interpretation, and my opinion too is that, for the present, these findings cannot be translated into da...
Conflict of Interest:
None declared. - Published on: 25 August 2004Alas animal modelsDear EditorShow More
Is it feasible to extrapolate animal findings to human medicine? We did not evolve (see http://www.kean.edu/~breid/chrom2.htm ). These chromosome numbers certainly do not support any evolutionary suppositions. Furthermore the mechanisms of meiosis serve to "fix" the chromosome numbers of sexually reproducing species. Is it not, therefore, dange...
Conflict of Interest:
None declared.