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Hyperglycaemic crises and lactic acidosis in diabetes mellitus
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  • Published on:
    Ketoacidosis and HHS
    • Anand CV, Professor of Biochemistry
    • Other Contributors:
      • Usha Anand

    Dear Editor

    We read with interest the educative review by Drs English and Williams,[1] and would like to congratulate the authors for their effort.

    The authors have raised a question- namely why ketoacidosis does not occur in HHS. Accumulation of ketone bodies in the blood in DKA stems from a greatly accelerated hepatic production rate, such that the capacity of non-hepatic tissues to use them, is exceeded....

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    Conflict of Interest:
    None declared.
  • Published on:
    Pathophysiology of diabetic ketoacidosis
    Dear Editor

    In their recent review English and Williams state "The primary mechanism for the development of ketoacidosis (DKA) and hyperglycaemic hyperosmolar state (HHS) is ... insulin deficiency per se ... together with a concomitant elevation of the counter-regulatory hormones" but "why ketoacidosis does not occur in HHS is unknown".[1]

    However, the pure existence of HHS is strong evidence against the sta...

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    Conflict of Interest:
    None declared.