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Evaluation of abnormal liver function tests
  1. J K Limdi1,
  2. G M Hyde2
  1. 1Tameside General Hospital, Ashton-under-Lyne, Manchester
  2. 2Wythenshawe Hospital, South Manchester University Hospitals NHS Trust, Wythenshawe, Manchester
  1. Correspondence to:
 Dr Jimmy K Limdi, Tameside General Hospital, Fountain Street, Ashton-under-Lyne OL6 9RW, UK; 


Interpretation of abnormalities in liver function tests is a common problem faced by clinicians. This has become more common with the introduction of automated routine laboratory testing. Not all persons with one or more abnormalities in these tests actually have liver disease. The various biochemical tests, their pathophysiology, and an approach to the interpretation of abnormal liver function tests are discussed in this review.

  • liver function tests
  • ALP, alkaline phosphatase
  • ALT, alanine transaminase
  • AST, aspartate transaminase
  • ELISA, enzyne linked immunosorbent assay
  • HbsAg, hepatitis B surface antigen
  • HFE, haemochromatosis gene
  • NASH, non-alcoholic steatohepatitis

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